What part of an amino acid distinguishes one amino acid from another?

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The R-group, or side chain, is the component of an amino acid that varies among different amino acids and gives each one its unique characteristics. While the amino group and the carboxyl group are essential structural features of all amino acids, they remain constant across the various amino acids and are not what differentiate them.

The amino group contains a basic group that can accept hydrogen ions (protons), and the carboxyl group is acidic, containing a carbon double-bonded to an oxygen and single-bonded to a hydroxyl (OH) group. These groups are responsible for the general properties of amino acids, but it is the R-group that determines each amino acid's specific identity, properties, and behavior in proteins.

The hydrogen atom is also a standard part of all amino acids, attached to the central carbon atom, and does not contribute to the differences among them. Therefore, it is the R-group that is crucial for distinguishing one amino acid from another, making it the correct answer.

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